OPC高表达PDGFRα、CSPG4等前体标志物，OL则富集PLP1、MOG等髓鞘基因，CRYAB表达差异达20倍（图2）。 值得注意的是，在OL组分中，童年虐待组 (DS-CA)的MOBP表达显著低于对照组，该基因编码髓鞘相关碱性蛋白，提示CA可能特异性影响髓鞘稳定性。

IM 后 6 个月至 1 年可检测到针对 CRYAB 的高亲和力抗体，其结合不受尿素变性影响，表明为亲和力成熟的应答。阻断实验证实，CRYAB 抗体与 EBNA-1 存在交叉反应，且补体固定活性显著。值得注意的是，仅在 EBV 血清阳性个体中检测到 CRYAB 抗体，血清阴性个体未检出，提示交叉反应与 EBV 感染直接相关。

Its connection with CRYAB began with an experiment that challenged orthodoxy: in 1995, van Noort et al. 2 reported CRYAB to be a predominant target of autoimmunity in MS.

When Cryab was administered one hour before and 12 hours after stroke onset, the lesion size at two days was not different between PBS- and Cryab-treated wild-type mice groups.

“CRYAB is expressed in oligodendrocytes in MS lesions and may have a protective effect by down-regulating proinflammatory responses of innate immune cells,” the team noted.

Citation: Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types DOI: 10.1016/j.isci.2022.103848 ...

In a test tube, compound 29 was able to prevent the aggregation of R120G cryAB, as well as partially reverse aggregation that had already occurred.