这种矛盾提示我们：是否因FOXP3在活化效应T细胞和肿瘤细胞中的非特异性表达，导致了对Treg功能的误判？ 昆明医科大学第三附属医院的研究团队在《Infectious Agents and Cancer》发表的研究，创新性地采用CD4、CD25、FOXP3三重标记策略，对103例NPC患者进行全切片扫描分析。

In contrast to a decline in Foxp3 expression of CD4+CD25+ T cells in the absence of IL-4, the addition of IL-4 led to sustained Foxp3 expression after 3 days of culture (Figure 6A, upper panel).

Regulatory T cells were characterised as CD4+FoxP3+; in addition, the expression of CD25, GITR and CTLA-4 among this population was also confirmed (Figure 1A).

Thymus-derived regulatory T cells (Tregs) expressing CD4, CD25, and the transcription factor Foxp3 play major roles in preventing autoimmunity. The Treg population is enriched in T cells expressing ...

Yanyan Qu, Shuguang Jin, Aijun Zhang, Baojun Zhang, Xiaoyun Shi, Junjie Wang, Yong Zhao, Gamma-Ray Resistance of Regulatory CD4⁺CD25⁺Foxp3⁺ T Cells in Mice ...

Their PBMC (peripheral blood mono nuclear cell) were harvested and investigated their character by FACScan (fluorescence-activated cell sorter scan) with fluorescent labeled antibodies (CD3, CD8, CD4, ...

Methods: We investigated the number of tumor-infiltrating FOXP3 (+) Tregs in formalin-fixed TNBC specimens which patients received palliative treatment in Samsung Medical Center between 1999 and 2007.