NK 3.3 cells are CD3-, CD4-, CD8-, CD2+, CD16+, CD56+. They are capable of strong NK cell lysis of sensitive target cells. NK 3.3 cells have been shown to kill by both perforin/granzyme mediated ...

In addition, the association of CD3 with the TCR–peptide–MHC complex transmits the activation signal to intracellular signalling molecules to initiate a signalling cascade in the T cell.

Among them, CD3 is considered to be the primary target. Image Credit: ACROBiosystems CD3 molecules tend to bind to TCR non-covalently to develop a TCR/CD3 receptor complex on the T-cell’s surface.

NK cells are immunophenotyped through staining using a fluorescent antibody panel to isolate CD3- CD56+ NK cells. Furthermore, the expression of the IgG Fc receptor III (CD16) on the NK cells ...

Human NK cells are a subset of peripheral blood lymphocytes defined by the expression of CD56 or CD16 and the absence of the T-cell receptor CD3. NK cells comprise of 10–15% of the lymphocyte ...

In Type 1 diabetes (T1D), insulin-producing β-cells are killed by islet-infiltrating immune cells in a process called “insulitis”. T1D results in a critical requirement for exogenous insulin and ...