为探究 CD2 相关蛋白（CD2AP）多态性与阿尔茨海默病（AD）关联机制，研究人员开展脑血管理 CD2AP 的研究。结果发现，脑血管 CD2AP 缺失与 AD 认知下降有关，且影响雄性小鼠记忆等。这为 AD 性别特异性治疗提供新靶点。

这篇研究揭示了管状循环内体（TRE）在膜运输中的关键作用，发现CIN85和CD2AP通过SH3结构域与支架蛋白MICAL-L1相互作用，被招募至TRE调控受体（如CD98）的循环过程。研究通过酵母双杂交、免疫共沉淀和功能实验证实，MICAL-L1依赖磷脂酸定位至TRE，并协调EHD1、肌动蛋白（actin）等分子促进内体裂变。该 ...

Our results reveal CD2AP neuronal requirements with relevance to AD susceptibility, including for proteostasis, calcium handling, and synaptic structure and function.” Joshua M. Shulman, MD, PhD, ...

CD2AP and synaptic integrity: A double-edged sword Synapse loss is a strong predictor of cognitive decline in AD, and CD2AP is crucial for maintaining synaptic structure and function.

The CD2AP data seemed to fit with a recent paper from Fan Liao in David Holtzman’s group at Washington University, St. Louis, showing that N2A cells expressing human APP made slightly more Aβ when ...

Microglial CD2AP levels are increased in AD, leading to elevated CSF1R signaling and C1q expression and cytoskeleton remodeling in microglia, resulting in the formation of disease-associated ...

“CD2AP is a fascinating molecule because it functions at the intersection of multiple pathways implicated in Alzheimer’s disease,” said Professor Yun-wu Zhang, corresponding author of the ...

The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity. The Journal of Neuroscience, April 2016 DOI: 10.1523/JNEUROSCI.2423-15.2016 ...

St. Louis, May 22, 2003 -- Mice lacking only one copy of the gene for CD2-associated protein (CD2AP) appear to be significantly more susceptible to kidney disease and failure than normal mice ...

Mice lacking only one copy of the gene for CD2-associated protein (CD2AP) appear to be significantly more susceptible to kidney disease and failure than normal mice. Moreover, the mutation appears ...