为探究 CD2 相关蛋白（CD2AP）多态性与阿尔茨海默病（AD）关联机制，研究人员开展脑血管理 CD2AP 的研究。结果发现，脑血管 CD2AP 缺失与 AD 认知下降有关，且影响雄性小鼠记忆等。这为 AD 性别特异性治疗提供新靶点。

"CD2AP是一个引人入胜的分子，因为它在阿尔茨海默病涉及的多条通路的交叉点发挥作用，"该综述的通讯作者张云武教授说。"通过了解它在不同脑 ...

CD2AP and synaptic integrity: A double-edged sword Synapse loss is a strong predictor of cognitive decline in AD, and CD2AP is crucial for maintaining synaptic structure and function.

Microglial CD2AP levels are increased in AD, leading to elevated CSF1R signaling and C1q expression and cytoskeleton remodeling in microglia, resulting in the formation of disease-associated ...

Our results reveal CD2AP neuronal requirements with relevance to AD susceptibility, including for proteostasis, calcium handling, and synaptic structure and function.” Joshua M. Shulman, MD, PhD, ...

More information: B. J. Harrison et al, The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity, Journal of Neuroscience (2016).

“CD2AP is a fascinating molecule because it functions at the intersection of multiple pathways implicated in Alzheimer’s disease,” said Professor Yun-wu Zhang, corresponding author of the ...

The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity. The Journal of Neuroscience, April 2016 DOI: 10.1523/JNEUROSCI.2423-15.2016 ...

Mice lacking only one copy of the gene for CD2-associated protein (CD2AP) appear to be significantly more susceptible to kidney disease and failure than normal mice. Moreover, the mutation appears ...