我们发现SC-macs高表达CD24和CD47的现象与衰老成纤维细胞和上皮细胞的研究结果一致，但创新性地揭示了RvD2能通过诱导Cleaved Caspase-3促进SC-macs凋亡。 虽然单独阻断"别吃我"信号能改善清除效率，但联合RvD2治疗才能达到最优效果，这为开发组合疗法提供了理论依据。

Pheast Therapeutics Inc. has announced the presentation of preclinical data for PHST-001, a therapeutic monoclonal antibody targeting CD24, a macrophage checkpoint.

Key Takeaways PHST001 targets CD24, a protein that helps tumors evade immune destruction, potentially enhancing immune response against cancer cells. The FDA's fast track designation accelerates the ...