Bioactivation of 5-FC enhances cytotoxicity beyond that seen by lytic replication alone. Early 5-FC initiation was more effective than late initiation in HT29 cells and this difference was more ...

"The results from this study underscore our confidence in PALI-2108 as a targeted treatment for moderate-to-severe UC," said Dr. Mitch Jones, CMO at Palisade Bio. "The successful bioactivation of ...

Carlsbad, CA, April 16, 2024-- Palisade Bio, Inc., a biopharmaceutical company focused on developing and advancing novel therapeutics for patients living with autoimmune, inflammatory, and ...

This allows the prodrug to break down in the areas of the GI tract where we are trying to deliver the active drug and confirms our previous findings of adequate bioactivation of PALI-2108 in NHV ...

Palisade Bio Inc. has completed its analysis evaluating ex vivo bioactivation of PALI-2108, an orally administered, locally acting colon-specific phosphodiesterase-4 (PDE4) inhibitor prodrug in ...

Palisade Bio, Inc, a biopharmaceutical company focused on developing and advancing novel therapeutics for patients living with autoimmune, inflammatory, and fibrotic diseases, has announced the ...

New in vitro Bioactivation Liver Response Assay used HEPATOPAC model to demonstrate utility of in vitro transcriptomic signature-based strategy in preclinical DILI risk assessment.

Kang, W., et al. (2020) Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the ...

The cardioprotective effect of the drug requires bioactivation of its thiophene moiety (a structural alert) by a cytochrome P450 enzyme to form a reactive sulfenic acid metabolite.

Researchers at biopharmaceutical firm Amgen have discovered a potential toxicity mechanism of a promising isothiazole-containing anticancer drug, and they have used the information to modify the ...