Kappa-opioid receptor (KOR) agonists represent a promising class of compounds that modulate pain, mood and various neurobehavioural processes. Unlike traditional opioids that primarily target the ...

Opioid medications offer people relief from debilitating pain, but these drugs come with dangers: the risk for addiction, miserable withdrawal symptoms and the potential for fatal overdose.

Opioid medications offer people relief from debilitating pain, but these drugs come with dangers: the risk for addiction, miserable withdrawal symptoms and the potential for fatal overdose. In a study ...

America remains in the grips of an opioid epidemic. Over the past 25 years or so, opioid overdose deaths have been rising steadily, reaching a record 81,806 in 2022, and not budging much since. Drugs ...

Opioids are some of the oldest known treatments for pain relief, but they can cause serious side effects. A team of researchers including Susruta Majumdar, a medicinal chemist and pharmacologist at ...

An experimental compound (gold) binds (dotted lines) to an unconventional spot within opioid receptors (turquoise) in the brain and therefore avoids some of the dangers associated with current opioid ...

University of Florida scientists have helped identify a novel drug compound that selectively activates pain-altering receptors in the body, offering a potentially safer alternative to conventional ...

Researchers have identified a compound that, in mice, makes naloxone much more effective at counteracting a drug overdose. The ongoing opioid epidemic in the U.S. kills tens of thousands of people ...

One of the greatest revolutions in the field of pain medication was the isolation of morphine from the opium poppy in the 19th century. Morphine molecules act as painkillers by attaching themselves to ...