The following studies were undertaken to develop a cultured uterine myocyte model which would allow further clarification of the adrenergic signal transduction mechanisms utilized by these myocytes.

Individuals with some forms of heart failure are treated with drugs that are known as beta-blockers because they target proteins known as beta-adrenergic receptors (beta-ARs). Now, a potential ...

IN the course of comprehensive studies of the mechanism of sympathetic function using the mouse iris as a working model we have demonstrated adrenergic α- and β-receptors and determined their dynamic ...

Alpha-1 adrenergic receptors (α1-ARs) are a subset of G protein-coupled receptors that play a pivotal role in cardiovascular homeostasis. While traditionally recognised for their involvement in ...

This is a preview. Log in through your library . Abstract Adrenergic and adrenolytic drugs were injected directly into the hypothalamus of the rat brain through permanently implanted cannulas and were ...

Beta-adrenergic signaling mechanisms are of central importance to cardiovascular health and disease. Modulation of these pathways represents an important pharmacologic approach to the treatment of ...

The addition of β-adrenergic antagonists to the treatment regimen for heart failure has validated the neurohormonal hypothesis and provided much-improved outcomes. This benefit had been in question ...

Noradrenaline is a neuromodulator secreted in the brain depending on behavioral context and physiological states of animal, influencing a wide range of physiological functions by modulating brain ...

IN patients with atrial arrhythmias the ventricular rate is primarily determined by the frequency of atrial-impulse generation and the functional refractory period of the atrioventricular node. It is ...

The Food and Drug Administration has granted Fast Track designation to APD418 (Arena Pharmaceuticals) for the treatment of decompensated heart failure. The Food and Drug Administration has granted ...

An article published in Science Advances describes for the first time a neuromuscular circuit that links the burning of muscle fat to the action of a protein in the brain. The findings, obtained in ...