The formation of a pH gradient, which is characterized by intracellular alkalinization and extracellular acidification, plays a key role in the growth and metastasis of tumor cells. However, the ...

Work now shows that the restricted proteolysis is due to alkalinization of the phagosome through Rab27a-dependent fusion with a subset of lysosomal vesicles bearing NADPH–oxidase complexes.

A nationwide study of 226 river-monitoring sites shows how humans are increasing salt levels in rivers. But alkalinization of rivers—rivers becoming less acidic—is also increasing, and is ...

Kanokporn Boonsirichai, John C. Sedbrook, Rujin Chen, Simon Gilroy, Patrick H. Masson, ALTERED RESPONSE TO GRAVITY Is a Peripheral Membrane Protein That Modulates Gravity-Induced Cytoplasmic ...

The research, by CSIRO Oceans and Atmosphere, Hobart, used a high-resolution model developed for the Great Barrier Reef region to study the impact of artificial ocean alkalinization on the acidity ...

In fact, river alkalinization has increased the fastest in areas underlain by carbonate rocks, at high elevations, and where acid rain or acid mine drainage is greatest.

Rapid alkalinization factors (RALFs) are required for pollen tube germination and elongation, an essential process in plant fertilization. But their role in monocot plants remains unexplored.

We studied the renal prevention offered by hyper-alkalinization without hyper-hydration. Methods: The dose of HDMTX was 8 (3pts) or 12g/m 2 (16pts), administered as a 4-hour infusion. Hypertonic 8.4% ...

"The acid rain problem is decreasing. But meanwhile, there are these lagging effects of river alkalinization showing up across a major region of the U.S.," said lead author Sujay Kaushal, an associate ...

Background: Renal failure is a severe acute toxicity of high-dose methotrexate (HDMTX), observed in near 2% of patients (pts). To prevent this risk, HDMTX is routinely given as single agent and ...