哈佛大学吴皓教授团队在国际顶尖学术期刊 Cell 上发表了题为：Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity 的研究论文【1】。 该研究发现了一种直接且特异性的gasdermin D（GSDMD）小分子激动剂——DMB，其能够在无需切割GSDMD的情况下激活GSDMD ...

Representational Photo The exploration of novel peptides for their potential impact on metabolic pathways has been a ...

It was February 1952, when then 25-year-old Elizabeth became Queen of England upon the death of her father King George. Her death in September 2022 ended her unmatched 70-year reign on the throne ...

Mazdutide also increased hepatic fatty acids oxidation via GCG receptor signalling and decreased HbA1c levels by 3.7mmol/mol ...

The race is on to develop the first daily weight-loss pill that would be both cheaper and less invasive than the current ...

As such, large pharmaceutical companies should consider going back to their ligand libraries and look for those with weak agonism that nonetheless affect phosphorylation, Auwerx suggests.

Incretin therapies based on GLP-1 receptor agonism aid in the loss of weight in obesity, but a relevant part of this loss (25%-40%) is attributed to loss of lean muscle mass, which raises the risk of ...

Statistically significant mean weight loss up to 5.5% over 28 days (4.9% placebo adjusted) Well-tolerated with no ...

CNW/ - Bright Minds Biosciences Inc. (NASDAQ: DRUG), a biotechnology company focused on developing novel therapies for neurological and ...

Bright Minds Biosciences announced the initiation of Phase 2 clinical trial of BMB-101 in a group of drug-resistant epilepsies and will discuss ...

Terns Pharmaceuticals Inc. (NASDAQ:TERN) revealed topline data from its Phase 1 single and multiple-ascending dose (SAD and ...