在血小板聚集过程中，ADP 激活整合素 αIIbβ3的具体机制尚未完全明晰。研究人员构建 P2Y1/P2Y12通路至 RAP1 调节的动力学系统模型，发现 P2Y12通路对整合素调节至关重要，该模型有助于理解血小板反应个体差异和治疗。

However, ADP exerts its effects via two receptors (P2Y1 and P2Y12). The new assay offers improved specificity by combining ADP with a fatty acid to attenuate nonspecific P2Y1 activation.

In the traditional test, ADP has been used as the activator, which is not specific only to the P2Y12 receptor. By using a combination of ADP and PGE1, the VerifyNow P2Y12 assay is specific to the ...

The receptor structure is shown as a yellow ribbon (bottom). The physiological ligand (ADP, top right-hand side) that stimulates the formation of blood clots, and the drug that suppresses platelet ...

Thus, clopidogrel hyporesponsiveness, as defined by ADP-induced turbidometric platelet aggregation, ADP-induced platelet aggregation measured by impedance (eg, Multiplate, Dynabyte), VerifyNow ...

In addition, elinogrel is the only molecule within the P2Y12 ADP receptor antagonist class that offers both an oral and i.v. route of administration, offering the potential to be the antiplatelet ...

These two outcomes combined for a lower risk of net adverse clinical events (NACE) in the P2Y12-inhibitor group (6.4% vs 7.2%; HR 0.89, 95% CI 0.81-0.98, P =0.020), with a number needed to treat ...

CHICAGO, IL (UPDATED)—Sending patients with NSTE ACS not pretreated with a P2Y12 adenosine diphosphate (ADP)-receptor antagonist to the catheterization laboratory for invasive angiography within 2 ...