Triptolide: pharmacological spectrum, biosynthesis, chemical …
网页2021年5月24日 · Triptolide, an abietane-type diterpenoid isolated from Tripterygium wilfordii Hook. F., has significant pharmacological activity. Research results show that triptolide has obvious inhibitory effects on many solid tumors.
Triptolide: reflections on two decades of research and prospects …
网页2021年4月28日 · This review highlights advances in material sourcing, molecular mechanisms, clinical progress and new drug design strategies for triptolide over the past two decades, along with some prospects for the future course of development of triptolide.
Triptolide: Medicinal chemistry, chemical biology and clinical …
网页2019年8月15日 · Advances in triptolide-inspiration medicinal chemistry. • Bioactive probes-based target identification of triptolide. • Clinical development progress of triptolide. • Future perspectives of triptolide.
Triptolide | C20H24O6 | CID 107985 - PubChem
网页Triptolide is an organic heteroheptacyclic compound, an epoxide, a gamma-lactam and a diterpenoid. It has a role as an antispermatogenic agent and a plant metabolite. ChEBI. Triptolide has been used in trials studying the treatment of HIV, Crohn's Disease, Intestinal Diseases, Gastrointestinal Diseases, and Digestive System Diseases, among others.
Mechanisms of cancer cell death induction by triptolide: A ...
网页2024年1月30日 · Based on the recent pre-clinical investigations, triptolide is linked to the induction of death of cancerous cells by triggering cellular apoptosis via inhibiting heat shock protein expression (HSP70), and cyclin dependent kinase (CDKs) by up regulating expression of P21.
Therapeutic potential of triptolide in autoimmune diseases and ...
网页2021年11月7日 · Triptolide exerts therapeutic effect by regulating the function of immune cells and the expression of cytokines through inflammatory signaling pathways, as well as maintaining redox balance and gut microbiota homeostasis.
Triptolide: Medicinal chemistry, chemical biology and clinical …
网页2019年8月15日 · In the past decades, triptolide has attracted considerable interests in the organic and medicinal chemistry society owing to its intriguing structure features and promising multiple pharmacological activities.
Genome of Tripterygium wilfordii and identification of …
网页2020年2月20日 · Triptolide is a trace natural product of Tripterygium wilfordii. It has antitumor activities, particularly against pancreatic cancer cells. Identification of genes and elucidation of the...
Triptolide - an overview | ScienceDirect Topics
网页Triptolide, a diterpene triepoxide, is a major active component of extracts derived from the medicinal plant Tripterygium wilfordii Hook F (TWHF). Triptolide has multiple pharmacological activities including anti-inflammatory, immune modulation, antiproliferative and proapoptotic activity.
Triptolide suppresses the growth and metastasis of non-small cell …
网页2021年4月23日 · Triptolide treatment concentration-dependently suppressed EMT in NCI-H1299 cells, evidenced by significantly elevated E-cadherin expression and reduced expression of ZEB1, vimentin, and slug.
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