Taxane - Wikipedia
网页Taxanes are a class of diterpenes. They were originally identified from plants of the genus Taxus (yews), and feature a taxadiene core. Paclitaxel (Taxol) and docetaxel (Taxotere) are widely used as chemotherapy agents. [2][3] Cabazitaxel was FDA approved to treat hormone-refractory prostate cancer.
Taxanes for Cancer - Cleveland Clinic
网页2023年4月18日 · Taxanes are chemotherapy drugs that stop cancer cells from replicating. The taxanes paclitaxel, docetaxel and cabazitaxel can effectively treat various forms of cancer. They’ve improved survival rates for cancer. Still, it’s important to understand what side effects may accompany treatment so you can plan for them.
A systemic review of taxanes and their side effects in metastatic ...
网页2022年10月11日 · Taxanes-containing chemotherapy constitutes an essential backbone for both early and metastatic breast cancer (mBC). However, the two major taxane drugs—paclitaxel and docetaxel—have distinct safety profiles. In this review, we summarize the safety outcome and management following …
A Comprehensive Review of Taxane Treatment in Breast Cancer: …
网页2024年4月29日 · Taxane-based chemotherapy regimens represent a cornerstone treatment modality for breast cancer, markedly enhancing progression-free survival and overall survival rates among patients .
Current Perspectives on Taxanes: Focus on Their Bioactivity, …
网页2021年3月17日 · Taxanes are natural diterpenoid substances occurring in yew plants, which received their name from a Latin term for yew, Taxus sp. The best known and to date the most clinically used taxane is paclitaxel (Figure 1).
Taxanes in cancer treatment: Activity, chemoresistance and its ...
网页Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor agents. However, their historic classification as antimitotics does not describe all their functions. Indeed, taxanes act in a complex ….
Docetaxel - NCI - National Cancer Institute
网页Docetaxel is a type of chemotherapy called a taxane. Taxanes interfere with structures in a cell called microtubules that help move chromosomes during mitosis (cell division). Docetaxel stops the growth of cancer cells and other dividing cells by blocking cell division.
Current Perspectives on Taxanes: Focus on Their Bioactivity, …
网页2021年3月17日 · Taxanes, mainly paclitaxel and docetaxel, the microtubule stabilizers, have been well known for being the first-line therapy for breast cancer for more than the last thirty years. Moreover, they have been also used for the treatment of ovarian, hormone-refractory prostate, head and neck, and non-sma ….
The taxanes: an update - The Lancet
网页2000年4月1日 · The taxanes are anticancer cytotoxics that stabilise cellular microtubules. Two members, paclitaxel and docetaxel have substantial activity. One or both agents are widely accepted as evidence-based components of therapy for advanced breast, lung, and ovarian carcinomas. Paclitaxel has recently been approved in …
Platinum drugs and taxanes: can we overcome resistance?
网页2021年6月26日 · Unlike most antitumor drugs, which damage DNA or RNA, the main mechanism of taxanes’ action is the promotion of cellular death through the binding of tubulin and the inhibition of the ...