Heparin-binding epidermal growth factor-like growth factor (HB-EGF…
网页HB-EGF is a member of the EGF family of ligands that is initially synthesized as a membrane-bound growth factor termed, proHB-EGF. The membrane bound proHB-EGF undergoes extensive proteolytic processing by several metalloproteinases capable of stimulating cellular proliferation.
Essential Roles of Heparin‐Binding Epidermal Growth Factor‐Like Growth ...
网页ProHB-EGF is cleaved by metalloproteases, known as a disintegrin and metalloproteases (ADAMs), to yield the soluble form of HB-EGF (sHB-EGF), through a process known as ectodomain shedding 2, 10. sHB-EGF binds to and activates the EGF receptor (ErbB1) 2 and ErbB4 4 to exert a potent mitogen and chemoattractant for a number of different cell ...
Heparin-Binding Epidermal Growth Factor–Like Growth Factor …
网页2018年11月1日 · Initially after protein synthesis, pro-HB-EGF contains a signal peptide and a propeptide. Membrane-bound HB-EGF contains an amino terminal heparin-binding domain, an EGF-like domain, and a juxtamembrane domain on the extracellular region, whereas the transmembrane domain spans the membrane and the cytoplasmic C-terminal domain is inside the cell.
Heparin‐binding epidermal growth factor‐like growth factor …
网页2007年3月29日 · Cleavage of membrane-anchored heparin-binding epidermal growth factor-like growth factor (proHB-EGF) yields a soluble HB-EGF isoform (sHB-EGF), which is an activating epidermal growth factor receptor (EGFR) ligand and a C-terminal fragment HB-EGF-C acting directly in the nucleus.
HB-EGF (Heparin-Binding EGF-Like Growth Factor)
网页2018年1月1日 · HB-EGF is a member of the EGF family of growth factors, which binds to and activates EGFR and ErbB4. HB-EGF is synthesized first as a transmembrane proHB-EGF. Ectodomain shedding of proHB-EGF yields sHB-EGF and HB-EGF-CTF. Each form of HB-EGF has a distinct biological activity, and functions in several modes of action.
Heparin-binding EGF-like growth factor: a juxtacrine growth factor
网页2000年12月1日 · Heparin-binding EGF-like growth factor (HB-EGF), which belongs to the EGF-family growth factors, is synthesized as a membrane-anchored form (proHB-EGF). Proteolytic cleavage of proHB-EGF at the extracellular domain yields the soluble form of HB-EGF (sHB-EGF).
Dual intracellular signaling by proteolytic cleavage of membrane ...
网页Abstract. Heparin-binding EGF-like growth factor (HB-EGF), a member of the EGF family, is synthesized as a membrane-anchored precursor (proHB-EGF) that is cleaved to release a soluble HB-EGF by specific metalloproteases. Proteolytic cleavage of proHB-EGF yields amino- and carboxy-terminal fragments (HB-EGF and HB-EGF-C).
Identification of the cancer cell proliferation and survival functions ...
网页Blocking proHB-EGF with Y-142 reduced spheroid formation, suppressed cell proliferation, and increased caspase activation in the 3D spheroid culture of NUGC-3 cells. Conclusions: Our results show that proHB-EGF acts as a cell proliferation and cell survival factor in …
Identification of the Cancer Cell Proliferation and Survival Functions ...
网页2013年1月21日 · The membrane-bound proHB-EGF is known to be a precursor of the soluble form of HB-EGF (sHB-EGF), which promotes cell proliferation and survival. While the functions of sHB-EGF have been extensively studied, it is not yet fully understood if proHB-EGF is also involved in cellular signaling events.
HB-EGF的胞外域脱落：癌症治疗的潜在目标,The Journal of …
网页2011年10月5日 · HB-EGF的胞外域脱落：癌症治疗的潜在目标. 肝素结合表皮生长因子样生长因子（HB-EGF）被合成为膜锚定蛋白，称为proHB-EGF。. 金属蛋白酶通过称为“胞外域脱落”的过程切割ProHB-EGF，导致形成可溶性HB-EGF。. proHB-EGF和可溶性HB-EGF均具有生物活性；前者通过邻苯二 ...
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