Lipofuscin - Wikipedia
网页Lipofuscin is the name given to fine yellow-brown pigment granules composed of lipid -containing residues of lysosomal digestion. [1][2] It is considered to be one of the aging or "wear-and-tear" pigments, found in the liver, kidney, heart muscle, retina, adrenals, nerve cells, and ganglion cells. [3] Formation and turnover.
Histology, Lipofuscin - StatPearls - NCBI Bookshelf
网页2023年5月1日 · Lipofuscin is a pigmented, heterogenous byproduct of failed intracellular catabolism conventionally found within lysosomes or the cytosol of aging postmitotic cells. Although it is present in virtually any cell type, phenotypically proliferative cells often dilute its concentration to an insignificant level. [1]
Lipofuscin: mechanisms of formation and increase with age
网页Lipofuscin (age pigment) is a brown-yellow, electron-dense, autofluorescent material that accumulates progressively over time in lysosomes of postmitotic cells, such as neurons and cardiac myocytes.
Lipofuscin - an overview | ScienceDirect Topics
网页Lipofuscin is a yellow-brown lipoprotein that accumulates as residual bodies in secondary lysosomes, especially in long-lived postmitotic cells, such as neurons and cardiac myocytes (Fig. 1-46), and especially in aged animals.
Lipofuscin, Its Origin, Properties, and Contribution to ...
网页2023年12月13日 · 2. Lipofuscin: Formation, Composition, and Potentially Harmful Effects. Lipofuscin is an intracellular deposit composed of lipids, proteins, and carbohydrates, which are cross-linked and highly modified by end products of glycation and/or lipid peroxidation [1,2,3,4,5,6]. It accumulates with age in the form of small yellow-orange granules ...
Lipofuscin and Aging: A Matter of Toxic Waste - Science
网页2005年2月2日 · Lipofuscin (which is used here in preference to ceroid, a term often used to denote disease-associated lipofuscin) is a complex mixture of oxidized protein and lipid degradation residues, along with lesser amounts of carbohydrates and metals.
An Overview of the Role of Lipofuscin in Age-Related ...
网页2018年7月4日 · One of the most striking morphologic changes in neurons during normal aging is the accumulation of lipofuscin (LF) aggregates, as well as, neuromelanin pigments. LF is an autofluorescent lipopigment formed by lipids, metals and misfolded proteins, which is especially abundant in nerve cells, cardiac muscle cells and skin.
Mini-Review on Lipofuscin and Aging: Focusing on The ...
网页2020年11月19日 · Intra-lysosomal accumulation of the autofluorescent “residue” known as lipofuscin, which is found within postmitotic cells, remains controversial. Although it was considered a harmless hallmark of aging, its presence is detrimental as …
What is lipofuscin? Defining characteristics and ...
网页2002年5月1日 · Lipofuscins, also known as age-pigments, have three defining characteristics: (1) they consist of intracellular secondary lysosomes; (2) they have a yellow autofluorescent emission when excited by near ultraviolet or blue light; and (3) they accumulate during normal senescence.
Lipofuscin: MedlinePlus Medical Encyclopedia
网页2023年2月2日 · Lipofuscin is a brownish pigment left over from the breakdown and absorption of damaged blood cells. Lipofuscin is found in heart muscle and smooth muscles. It is also called the aging pigment.