Isatin - Wikipedia
网页Isatin, also known as tribulin, is an organic compound derived from indole with formula C 8 H 5 NO 2. The compound was first obtained by Otto Linné Erdman [1] and Auguste Laurent [2] in 1840 as a product from the oxidation of indigo dye by nitric acid and chromic acids.
Isatin | C8H5NO2 | CID 7054 - PubChem
网页Isatin is an indole derivative first obtained by Erdman and Laurent in 1841 as an oxidation product of Indigo dye with nitric acid and chromic acids. The compound is found in many plants and Schiff bases of Isatin are have been investigated for pharmaceutical applications.
Isatin and its derivatives: a survey of recent syntheses, reactions ...
网页2019年3月3日 · In this review, we have reported several novel methods for the synthesis of N -, C2-, and C3-substituted and spiro derivatives of isatin. The isatin moiety also shows important chemical reactions such as oxidation, ring expansion, Friedel–Crafts reaction and aldol condensation.
Therapeutic Outcomes of Isatin and Its Derivatives against …
网页2022年2月22日 · Isatin (1H indole 2, 3-dione) is a heterocyclic, endogenous lead molecule recognized in humans and different plants. The isatin nucleus and its derivatives are owed the attention of researchers due to their diverse pharmacological activities such as anticancer, anti-TB, antifungal, antimicrobial, antioxidant, anti-inflammatory, …
Isatin - an overview | ScienceDirect Topics
网页2010年8月2日 · Isatin is a chemical compound that serves as a scaffold for many biologically active agents, particularly antitumor drugs. It can be modified at various positions to create different biologically active compounds.
Isatin, an endogenous nonpeptide biofactor: A review of its …
网页Isatin (indole-2,3-dione) is an oxidized indole. It is widely distributed in mammalian tissues and body fluids, where isatin concentrations vary significantly from <0.1 to > 10 µM. Isatin output is increased under conditions of stress. Exogenously administered isatin is characterized by low to …
A Mini Review on Isatin, an Anticancer Scaffold with Potential ...
网页2022年4月27日 · Isatin, chemically an indole-1 H -2,3-dione, is recognised as one of the most attractive therapeutic fragments in drug design and development. The template has turned out to be exceptionally useful for developing new anticancer scaffolds, as evidenced by the increasing number of isatin-based molecules which are either in clinical use or in …
Isatin: A Scaffold with Immense Biodiversity - PubMed
网页Isatin is an endogenous and a significant category of fused heterocyclic components and has widely been a part of several potential biologically useful synthetics. Since its discovery, tons of research work has been conducted with respect to the synthesis, chemical properties, and biological and ind ….
Biochemical and pharmacological characterization of isatin …
网页Isatin, 1H-indole-2,3-dione, is a heterocyclic compound of significant importance in medicinal chemistry. It is a synthetically versatile molecule, a precursor for a large number of pharmacologically active compounds.
Isatin: Uses, Interactions, Mechanism of Action - DrugBank Online
网页2005年6月13日 · Isatin is an indole derivative first obtained by Erdman and Laurent in 1841 as an oxidation product of Indigo dye with nitric acid and chromic acids. The compound is found in many plants and Schiff bases of Isatin are have been investigated for pharmaceutical applications.