Wnt/β-catenin signalling: function, biological mechanisms, …
网页2022年1月3日 · The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often...
The origin and evolution of Wnt signalling - Nature
网页2024年2月19日 · Wnt signalling is a crucial developmental pathway involved in various processes such as cell differentiation and the formation and polarity of the primary body axis 1. It is involved in all...
Everything You Would Like to Know About Wnt Signaling
网页2013年5月14日 · Wnts are secreted glycoproteins that bind to specific cell surface receptors and activate signaling in a mostly paracrine fashion. Wnts trigger distinct intracellular pathways, including canonical signaling through β-catenin and noncanonical planar cell polarity (PCP) and Ca 2+ signaling (Fig. 1).
Wnt/β-Catenin Signaling and Disease - Cell Press
网页This article reviews the Wnt/β-catenin signaling pathway, a conserved developmental cascade that regulates various biological processes and is involved in many human diseases. It covers the structure, function, and regulation of Wnt proteins, receptors, co-receptors, and transcription factors, as well as the genetic and molecular mechanisms of …
WNT signalling in the immune system: WNT is spreading its …
网页2015年4月7日 · WNT signalling regulates aspects of peripheral T-cell activation and migration. WNT signalling is also involved in dendritic cell (DC) maturation, and activation of WNT signalling increases...
The Wnt Homepage - Stanford University
网页Wnt proteins are highly conserved in evolution and are active in every branch of the animal kingdom. Wnt signaling is often implicated in stem cell control, as a proliferative and self-renewal signal.
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases …
网页A review of the canonical Wnt pathway that regulates cell proliferation, polarity, and fate via β-catenin stabilization and transcription. Learn about Wnt ligands, receptors, antagonists, and their roles in development and human diseases.
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
网页A comprehensive overview of Wnt/β-catenin signaling, a key regulator of development and stem cells, and its role in disease and potential therapies. Learn about the structure, function, and evolution of Wnt proteins, receptors, and co-receptors, and how they control cell proliferation, differentiation, and morphogenesis.
Wnt Pathway: An Integral Hub for Developmental and Oncogenic …
网页2020年10月28日 · In this review, we provide an overview of the key components of the Wnt signaling pathway and the milestones in both developmental and cancer biology. We also describe some recently discovered components and functions and emerging links of Wnt signaling with cancer stemness and antitumor immunity.
Mechanisms of Wnt signaling and control - PMC - National …
网页Wnt functions extend into adulthood where they regulate stem cell behavior, tissue homeostasis, and damage repair. Disruption of Wnt signaling activity during embryonic development or in adults results in a spectrum of abnormalities and …
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