SOS1 Gene - GeneCards | SOS1 Protein | SOS1 Antibody
网页2024年8月6日 · SOS1 (SOS Ras/Rac Guanine Nucleotide Exchange Factor 1) is a Protein Coding gene. Diseases associated with SOS1 include Noonan Syndrome 4 and Fibromatosis, Gingival, 1. Among its related pathways are Downstream signaling of activated FGFR2 and Prolactin Signaling.
Co-targeting SOS1 enhances the antitumor effects of KRAS - Nature
网页2024年8月5日 · Here, we assessed the antitumor responses of KRASG12C mutant lung and colorectal cancer models to combination treatment with a SOS1 inhibitor (SOS1i), BI-3406, plus the KRASG12C inhibitor,...
Structural and functional insight into the regulation of SOS1 activity
网页2023年10月26日 · We report the high-resolution cryo-electron microscopy structures of SOS1, a major determinant of salt tolerance in plants.
Small molecule Son of Sevenless 1 (SOS1) inhibitors: a review …
网页Son of Sevenless 1 (SOS1) is a central node in RAS signaling pathways and modulation of SOS1-mediated RAS activation represents a unique opportunity for treating RAS-addicted cancers.
Critical requirement of SOS1 RAS-GEF function for mitochondrial ...
网页2021年6月12日 · SOS1 ablation causes specific defective phenotypes in MEFs including increased levels of intracellular ROS.
SOS1 gene - MedlinePlus
网页The SOS1 gene provides instructions for making a protein that is involved in controlling (regulating) the activation of the RAS/MAPK signaling pathway, which helps control several important cell functions. Learn about this gene and related health conditions.
Identification and Characterization of Oncogenic SOS1 ... - PubMed
网页Recent exome sequencing analysis has identified SOS1, encoding a guanine nucleotide exchange factor, as significantly mutated in lung adenocarcinomas lacking canonical oncogenic RTK/Ras/Raf pathway mutations.
Sos1 disruption impairs cellular proliferation and viability …
网页2016年5月9日 · Cellular proliferation and migration were impaired in Sos1-KO and Sos1/2-DKO MEFs in comparison with WT and Sos2-KO MEFs, whereas cell adhesion was only impaired upon depletion of both Sos...
SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 [Homo …
网页2024年8月27日 · This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding …
SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 [ (human)]
网页This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins.
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