Kininogen - Wikipedia
网页Kininogens are precursor proteins for kinins, biologically active polypeptides involved in blood coagulation, vasodilation, smooth muscle contraction, inflammatory regulation, and the regulation of the cardiovascular and renal systems. Types of kininogen.
Contribution of Coagulation Pathways and Fibrinolysis in …
网页2006年11月16日 · The main purpose of this study was to characterize the kininogenase activity of plasma kallikrein, thrombin (factor IIa), factor Xa, and plasmin in a purified system. We also aimed at characterizing the kinetic profile of generation of kinins in a whole blood system where coagulation and fibrinolysis were monitored by thromboelastography.
Frontiers | The Plasma Kallikrein–Kininogen Pathway Is Critical in …
网页The kallikrein–kinin system (KKS) consists of two serine proteases, prekallikrein (pKal) and factor XII (FXII), and a cofactor, high-molecular-weight kininogen (HK). Upon activation of the KKS, HK is cleaved to release bradykinin.
Frontiers | Therapeutic Values of Human Urinary Kallidinogenase …
网页2018年6月4日 · Human Urinary Kallidinogenase (HUK) extracted from human urine is a member of tissue kallikrein which could convert kininogen to kinin and hence improve the plasma kinin level. Medical value of HUK has been widely investigated in China, especially on acute ischemic stroke.
Pancreatic Kininogenase Ameliorates Renal Fibrosis in …
网页2016年1月8日 · Pancreatic kininogenase (PKase), which extracted from pig pancreas tissue, has been reported as one of the main drugs for the treatment of DN through promoting the release of kinins .
The role of kininogenases, kinin formation and kininogenase
网页Summary. The kinin system has for a long time been considered to play a role in the pathophysiology of trauma, particularly in blood pressure changes and in inflammatory effects. Recent findings necessitate a revision of this view.
Kinins—II: Biochemistry, Pathophysiology, and Clinical Aspects ...
网页Kininogenase Activity and Kinin-Like Substance in the Venomous Spicules and Spines of Lepidopteran Larvae. F. Kawamoto, N. Kumada
A Micro-Kininogenase Assay for Studies of Kallikrein in Renal ...
网页The kininogenase activity is widely determined for the estimation of kallikrein in urine (1), kidney homogenates (2) and in nephron segment homogenates (3,4,5). The technique involves incubation of samples with kininogen for a specified time and analysis of the...
网页Kininogenases such as trypsin, plasma kallikrein, and tissue kallikreins are unlikely to be the natural processing enzymes. for this system since T-kininogen was shown to be resistant to cleavage by both plasma and tissue kallikreins, and only very high concentrations of trypsin can cause the release of.
The Therapeutic Effect of Pancreatic Kininogenase on Treatment …
网页Background: To determine the therapeutic efficacy and cost-effective of pancreatic kininogenase (PKase) on treatment of diabetic peripheral neuropathy (DPN) compared with Prostaglandin E1 (PGE1) in patients with type 2 diabetes.