GAD antibodies in neurological disorders - Nature
网页2020年5月26日 · The main neurological syndromes associated with high levels of antibodies to glutamic acid decarboxylase (GAD) include stiff-person syndrome, cerebellar ataxia and temporal lobe epilepsy.
GAD67-mediated GABA Synthesis and Signaling Impinges on …
网页gamma-Aminobutyric Acid. Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the central nervous system, synthesized by two isoforms of glutamate decarboxylase (GAD): GAD65 and GAD67.
GAD67-Mediated GABA Synthesis and Signaling Regulate …
网页2007年6月21日 · GAD67 and GAD65 show striking differences in subcellular localization, enzyme activity, and gene regulation and likely contribute to distinct as well as overlapping pools of GABA synthesis (Soghomonian and Martin, 1998).
Glutamate Decarboxylase 67 - an overview | ScienceDirect Topics
网页Glutamic acid decarboxylase 67 (GAD67) is one of the isoforms that catalyze GABA synthesis. Subcutaneous inoculation of the GAD-expressing HSV vector transduces DRG neurons to produce GAD67 and release GABA, and the HSV vector reduces spinal cord injury-induced neuropathic pain (Liu et al., 2004).
Glutamate Decarboxylase 67 Deficiency in a Subset of GABAergic …
网页2015年4月23日 · Decreased expression of the GABA synthetic enzyme glutamate decarboxylase 67 (GAD67) in a subset of GABAergic neurons, including parvalbumin (PV)-expressing neurons, has been observed in...
GABAergic inhibitory neurons as therapeutic targets for cognitive ...
网页2018年3月22日 · Decreased GAD67 mRNA is selectively observed in a subpopulation of prefrontal cortex (PFC) GABA neurons that express the calcium-binding protein parvalbumin (PV) 19,22. Around 45% of PV-mRNA ...
Neurological Disorders Associated with Glutamic Acid Decarboxylase ...
网页2019年5月23日 · Glutamic acid decarboxylase (GAD) enzymes are found in the central nervous system (CNS). GAD can exist in two different isoforms, GAD65 and GAD67. GAD enzymes are essential for the formation of gamma aminobutyric acid (GABA), an inhibitory neurotransmitter in the brain [1].
Investigating the Role of GABA in Neural Development and …
网页2022年7月19日 · GAD67- and GAD65-mediated synthesis of GABA differ in a temporospatial manner . GAD67 contributes to over 90% of basal GABA synthesis and is distributed throughout the cell, while GAD65 remains localised to presynaptic nerve terminals (Figure 1).
The regulation of glutamic acid decarboxylases in GABA ...
网页2019年11月30日 · Dysregulation of GADs has been implicated in various neurological disorders including epilepsy and schizophrenia. Two isoforms of GADs, GAD67 and GAD65, are expressed from separate genes and have different regulatory processes and …
Frontiers | Glutamic acid decarboxylase 67 expression by a distinct ...
网页2014年12月16日 · Glutamate decarboxylase exists as two major isoforms, termed GAD65 and GAD67, that are usually expressed in GABA-containing neurons in the central nervous system. GAD65 has been proposed to be associated with GABA exocytosis whereas GAD67 with GABA metabolism.
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